Eise Eisinga was born in Dronrijp on February 21, 1744. He attended primary school there. Like many children, at that time, he had to work at home, which his case was in his father's wool combing establishment. In addition to combing wool, he inherited his father's interest in matters such as astronomy and mathematics. He was so curious that he went to Franeker every week, where he studied Euclides's maths books with Willem Wijtses, a wool dyer. At the age of 24, Eisinga married Pietje Jacobs, after which he settled in Franeker in 1768, working as a wool comber.